Sorafenib interacts with multiple intracellular (CRAF, BRAF) and cell surface kinases (KIT, FLT-3, VEGFR-2, VEGFR-3, and PDGFR-ß). Several of these kinases are thought to be involved in angiogenesis, thus Sorafenib reduces blood flow to the tumor.

Sorafenib decreases the proliferation of tumor cells.

Cisapride: both increase QTc interval.
Dronedarone:
Pimozide, Thioridazine and Ziprasidone: both increase QTc interval.
Amiodarone: both increase QTc interval.
Anticonvulsants (Carbamazepine, Phenobarbital and phenytoin): decreases levels of sorafenib by increasing metabolism.
Dexamethasone: decreases levels of sorafenib.
Rifampin: decreases levels of sorafenib by increasing metabolism.

You will be checked regularly by your health care professional while you are taking Sorafenib, to monitor side effects and check your response to therapy. Periodic blood work to monitor your complete blood count (CBC) as well as the function of other organs will also be ordered by your doctor.

• Common side effects: Acne, dry skin, itching or skin rash, nausea, vomiting, diarrhea, patchy hair loss, loss of appetite, stomach pain, dry mouth, tiredness, hypertension, heart failure, anemia.

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